Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GALR2 | O43603 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968366 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL550921 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL10514258 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL20968303 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL7723906 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL2527342 | 0.86 | ALDH1A1 (0.57) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL550516 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL17737227 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKMT2AARMEN1 | |
| SCHEMBL14114749 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL3299225 | 0.85 | CA12 (0.62) | SMN1; SMN2MAPTNPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417362-B1 | PIPERAZINE DERIVATIVES; ARTERIOSCLEROSIS, PANCREATITIS, AND CARDIOVASCULAR DISORDER TREATMENT; SIDE EFFECT REDUCTION | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-09 | — | — | US | disclosed |