Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.30 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662876 | 0.91 | CA12 (0.37) | CA12CA1CA9CA2KDR | |
| SCHEMBL7659554 | 0.90 | CA12 (0.36) | CA12CA1CA9CA2KDR | |
| SCHEMBL7657220 | 0.86 | CAMK2D (0.42) | KDR | |
| SCHEMBL7652600 | 0.85 | ACKR3 (0.33) | ACKR3CA12CA1CA9CA2 | |
| Acetic Acid SCHEMBL7662873 | 0.85 | CA12 (0.37) | ACKR3CA12CA1CA9CA2 | |
| SCHEMBL12856392 | 0.83 | MEN1 (0.40) | ACKR3CA12CA1CA9CA2 | |
| Acetic Acid SCHEMBL7665482 | 0.82 | CA12 (0.36) | ACKR3CA12CA1CA9CA2 | |
| Acetic Acid SCHEMBL7852409 | 0.82 | CA12 (0.36) | ACKR3CA12CA1CA9CA2 | |
| Acetic Acid SCHEMBL8516673 | 0.81 | CAMK2D (0.37) | ACKR3CA12CA1CA9CA2 | |
| Acetic Acid SCHEMBL7658062 | 0.81 | ACKR3 (0.35) | ACKR3CA12CA1CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |