Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665809 | 0.89 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL7535016 | 0.73 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL7779716 | 0.69 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL7566830 | 0.67 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL7779400 | 0.65 | PTGS2 (0.84) | PTGS2PTGS1 | |
| SCHEMBL8765159 | 0.65 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL8765838 | 0.65 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL9206986 | 0.65 | PTGS2 (0.73) | PTGS2PTGS1DRD1 | |
| SCHEMBL7780841 | 0.64 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL7539374 | 0.63 | PTGS2 (0.50) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |