Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.38 |
| ▸ | CDK2 | P24941 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672785 | 0.81 | PDGFRA (0.48) | CTSLPDGFRACCNE1CDK2NPC1 | |
| SCHEMBL7675152 | 0.80 | PDGFRA (0.43) | CTSLPDGFRACCNE1CDK2ADORA2A | |
| SCHEMBL7668634 | 0.80 | CCNE1 (0.54) | CTSLPDGFRACCNE1CDK2ADORA2A | |
| SCHEMBL7667683 | 0.78 | CCNE1 (0.55) | CTSLPDGFRACCNE1CDK2NPC1 | |
| SCHEMBL7668440 | 0.77 | CCNE1 (0.51) | PDGFRACCNE1CDK2ADORA2A | |
| SCHEMBL7672318 | 0.76 | PDE1A (0.43) | CTSLPDGFRACCNE1CDK2HTT | |
| SCHEMBL7666287 | 0.76 | PDGFRA (0.41) | CTSLPDGFRACCNE1CDK2ADORA2A | |
| SCHEMBL7664310 | 0.75 | CDK2 (0.42) | CTSLPDGFRACCNE1CDK2RAB9A | |
| SCHEMBL7667689 | 0.75 | KCNH3 (0.46) | CTSLPDGFRACCNE1CDK2 | |
| SCHEMBL7670452 | 0.75 | LRRK2 (0.38) | PDGFRACCNE1CDK2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |