Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558975 | 0.93 | ADORA3 (0.51) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL6998913 | 0.90 | ADORA1 (0.52) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7666412 | 0.85 | ADORA1 (0.51) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7656557 | 0.84 | ADORA3 (0.58) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7668320 | 0.84 | ADORA1 (0.53) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7666682 | 0.84 | ADORA3 (0.50) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7662109 | 0.83 | ADORA1 (0.48) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7663888 | 0.83 | ADORA2B (0.40) | ADORA3ADORA1ADORA2AADORA2BCYP1A2 | |
| SCHEMBL7662113 | 0.82 | ADORA1 (0.51) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL7666680 | 0.80 | ADORA3 (0.47) | ADORA3ADORA1ADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |