Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766712 | 1.00 | TRPV1 (1.00) | TRPV1HDAC4HDAC6KCNH2 | |
| SCHEMBL1686894 | 0.87 | TRPV1 (0.77) | TRPV1HDAC4HDAC6 | |
| SCHEMBL1686892 | 0.87 | TRPV1 (0.77) | TRPV1HDAC4HDAC6 | |
| SCHEMBL766636 | 0.85 | TRPV1 (1.00) | TRPV1HDAC4HDAC6 | |
| SCHEMBL766635 | 0.85 | TRPV1 (1.00) | TRPV1HDAC4HDAC6 | |
| SCHEMBL766658 | 0.85 | TRPV1 (1.00) | TRPV1KCNH2 | |
| SCHEMBL766657 | 0.85 | TRPV1 (1.00) | TRPV1KCNH2 | |
| SCHEMBL766536 | 0.78 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL766721 | 0.77 | TRPV1 (0.80) | TRPV1KCNH2 | |
| SCHEMBL766722 | 0.77 | TRPV1 (0.80) | TRPV1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885HDAC4 966/4885HDAC6 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.