Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.52 |
| ▸ | RARG | P13631 | 13/20 | 0.52 |
| ▸ | RARA | P10276 | 8/20 | 0.52 |
| ▸ | RARB | P10826 | 8/20 | 0.52 |
| ▸ | RXRB | P28702 | 4/20 | 0.52 |
| ▸ | RXRG | P48443 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667223 | 1.00 | RXRA (0.52) | RXRARARGRARARARBRXRB | |
| SCHEMBL7666971 | 0.83 | TBXAS1 (0.45) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL7666975 | 0.83 | TBXAS1 (0.45) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL7666969 | 0.83 | TBXAS1 (0.45) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL10558322 | 0.79 | RXRA (0.54) | RXRARARGRARARARBRXRB | |
| SCHEMBL8145980 | 0.75 | RXRA (0.56) | RXRARARGRARARARBRXRB | |
| SCHEMBL8145985 | 0.75 | RXRA (0.56) | RXRARARGRARARARBRXRB | |
| SCHEMBL10562459 | 0.75 | RXRA (0.57) | RXRARARGRARARARBRXRB | |
| SCHEMBL8145984 | 0.75 | RXRA (0.56) | RXRARARGRARARARBRXRB | |
| SCHEMBL8151970 | 0.74 | RXRA (0.65) | RXRARARGRARARARBRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420363-B1 | Mono- or polyenic carboxylic acid derivatives | EISAI CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| US-6291508-B1 | POTENT ABILITY TO BIND TO RETINOIC ACID RECEPTORS THUS USEFUL IN TREATING PSORIASIS AND RHEUMATOID ARTHRITIS. | EISAI CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| US-6133283-A | Mono- or polyenic carboxylic acid derivatives | EISAI CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| US-6030964-A | BINDS TO RETINOIC ACID RECEPTORS AND USEFUL FOR TREATING PSORIASIS, AUTOIMMUNE DISEASES, TUMORS, RHEUMATOID ARTHRITIS AND FOR INDUCING IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION | EISAI CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-5977125-A | Mono-or polyenic carboxylic acid derivatives | EISAI CO., LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0790228-A1 | MONO- OR POLYENIC CARBOXYLIC ACID DERIVATIVE | Eisai Co., Ltd. (JP) | 1997-08-20 | — | — | EP | disclosed |