Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.32 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.32 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.32 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722669 | 0.67 | ALDH1A1 (0.46) | MAP3K11TLK2NEK7NEK6PDPK1 | |
| SCHEMBL2808756 | 0.65 | SRC (0.33) | — | |
| SCHEMBL807493 | 0.62 | MAP3K11 (0.38) | MAP3K11TLK2NEK7NEK6PDPK1 | |
| SCHEMBL15757795 | 0.61 | PDPK1 (0.40) | MAP3K11TLK2NEK7NEK6PDPK1 | |
| SCHEMBL2576996 | 0.61 | PDPK1 (0.52) | MAP3K11TLK2NEK7NEK6PDPK1 | |
| SCHEMBL12321662 | 0.60 | NOTUM (0.41) | MAP3K11TLK2NEK7NEK6 | |
| SCHEMBL13166536 | 0.60 | MAPT (0.50) | — | |
| SCHEMBL2356090 | 0.59 | MAP3K11 (0.55) | MAP3K11TLK2NEK7NEK6PDPK1 | |
| SCHEMBL18468170 | 0.59 | TDP2 (0.35) | — | |
| SCHEMBL16334090 | 0.58 | KDM4E (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559815-B1 | OPTICALLY ACTIVE THIAZOLOISOINDOLINONE DERIVATIVES WITH AN ANTIVIRAL ACTION | BOEHRINGER MANNHEIM GMBH (DE) | 1995-09-06 | — | — | EP | claimed |
| US-6492398-B1 | CYCLIN DEPENDENT KINASE 11 INHIBITORS; PREVENTING OR REDUCING SEVERITY OF EPITHELIAL CYTOTOXICITY SIDE-EFFECTS, E.G. ALOPECIA, PLANTAR-PALMAR SYNDROME, MUCOSITIS INDUCED BY CHEMOPTHERAPY AND/OR RADIATION THERAPY | SMITHKLINE BEECHMAN CORPORATION | 2002-12-10 | — | — | US | disclosed |
| CN-1355807-A | Thiazoloindolinone compounds | GLAXO GROUP LTD (GB) | 2002-06-26 | — | — | CN | disclosed |
| CN-1355807-A | Thiazoloindolinone compounds | GLAXO GROUP LTD (GB) | 2002-06-26 | — | — | CN | disclosed |