SCHEMBL7668484

SCHEMBL7668484

O=c1c(Cc2cccnc2)cn2c3c(cc(OCn4nnc5ccccc54)cc13)Sc1ccc(Br)cc1-2

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTK2 Q05397 2/20 0.33
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7674089 0.94 PTK2 (0.32) PTK2
SCHEMBL7666731 0.93 PTK2 (0.33) PTK2RAB9A
SCHEMBL7674317 0.93 PTK2 (0.36) PTK2RAB9A
SCHEMBL7669107 0.86 PTK2 (0.34) PTK2RAB9A
SCHEMBL7662091 0.86 KCNA5 (0.34) PTK2RAB9A
SCHEMBL7666498 0.86 KCNA5 (0.34) PTK2RAB9A
SCHEMBL7673333 0.86 PTK2 (0.32) PTK2
SCHEMBL7668560 0.85 PTK2 (0.33) PTK2RAB9A
SCHEMBL7669036 0.85 PTK2 (0.34) PTK2RAB9A
SCHEMBL7669032 0.85 LRRK2 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6476021-B1 Compounds having cGMP-PDE inhibitory effect MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2002-11-05 US disclosed
EP-1048666-A1 NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-11-02 EP disclosed