Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666498 | 0.97 | KCNA5 (0.34) | KCNA5KCNJ5KCNJ3RAB9AMEN1 | |
| SCHEMBL7671531 | 0.90 | FPR1 (0.32) | RAB9ACYP1A2CYP3A4CYP2C9PTK2 | |
| SCHEMBL7666445 | 0.89 | FPR1 (0.32) | RAB9ACYP1A2CYP3A4CYP2C9PTK2 | |
| SCHEMBL7669036 | 0.86 | PTK2 (0.34) | RAB9ACYP1A2CYP3A4CYP2C9PTK2 | |
| SCHEMBL7669107 | 0.86 | PTK2 (0.34) | RAB9ACYP1A2CYP3A4CYP2C9PTK2 | |
| SCHEMBL7672395 | 0.86 | PTK2 (0.32) | KCNA5KCNJ5KCNJ3PTK2 | |
| SCHEMBL7668484 | 0.86 | PTK2 (0.33) | RAB9APTK2 | |
| SCHEMBL7674089 | 0.86 | PTK2 (0.32) | PTK2 | |
| SCHEMBL7673333 | 0.86 | PTK2 (0.32) | PTK2 | |
| SCHEMBL7668560 | 0.85 | PTK2 (0.33) | RAB9ACYP1A2CYP3A4CYP2C9PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |