Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.35 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382580 | 0.82 | NOTUM (0.44) | MAPTNOTUMHSD17B3ALDH1A1MEN1 | |
| SCHEMBL6752845 | 0.81 | NOTUM (0.59) | MAPTGPR119NOTUMTACR1BRD4 | |
| SCHEMBL7669258 | 0.80 | NOTUM (0.57) | MAPTGPR119NOTUMTACR1BRD4 | |
| SCHEMBL3530939 | 0.79 | NOTUM (0.44) | MAPTGPR119NOTUMTACR1ALDH1A1 | |
| SCHEMBL7668885 | 0.77 | GPR119 (0.41) | MAPTGPR119NOTUMHSD17B3TACR1 | |
| SCHEMBL15686279 | 0.75 | KDM1A (0.45) | MAPTGPR119NOTUMKDM1AALDH1A1 | |
| SCHEMBL15663537 | 0.75 | NOTUM (0.48) | MAPTGPR119NOTUMTACR1ALDH1A1 | |
| SCHEMBL7668882 | 0.75 | GPR119 (0.41) | MAPTGPR119NOTUMHSD17B3TACR1 | |
| SCHEMBL18593249 | 0.73 | NOTUM (0.64) | MAPTNOTUMKDM1ABCHE | |
| SCHEMBL6754930 | 0.73 | GPR119 (0.42) | MAPTGPR119NOTUMKDM1ATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369221-B1 | Thiazolobenzoheterocycles, preparation and medicines containing same | AVENTIS PHARMA S.A. (FR) | 2002-04-09 | — | — | US | disclosed |