Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752845 | 0.96 | NOTUM (0.59) | NOTUMMPOKDM4EBRD4MAPT | |
| SCHEMBL18216843 | 0.86 | KDM4E (0.53) | NOTUMMPOKDM4EBRD4GPR119 | |
| SCHEMBL7668576 | 0.83 | PDK1 (0.56) | NOTUMMPOKDM4EBRD4MAPT | |
| SCHEMBL18109844 | 0.82 | ABHD6 (0.53) | MPOKDM4EBRD4GPR119HSD17B10 | |
| SCHEMBL3530939 | 0.82 | NOTUM (0.44) | NOTUMMPOKDM4EBRD4MAPT | |
| SCHEMBL7382818 | 0.82 | NOTUM (0.62) | NOTUMKDM4EMAPTHTR2AHTR2C | |
| SCHEMBL30767099 | 0.81 | NOTUM (0.59) | NOTUMKDM4EMAPTHTR2AHTR2C | |
| SCHEMBL5696394 | 0.81 | NOTUM (0.59) | NOTUMKDM4EMAPTHTR2AHTR2C | |
| SCHEMBL31552767 | 0.81 | NOTUM (0.55) | NOTUMMPOKDM4EBRD4GPR119 | |
| SCHEMBL4691685 | 0.81 | NOTUM (0.55) | NOTUMMPOKDM4EBRD4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369221-B1 | Thiazolobenzoheterocycles, preparation and medicines containing same | AVENTIS PHARMA S.A. (FR) | 2002-04-09 | — | — | US | disclosed |