SCHEMBL76693

SCHEMBL76693

COc1ccc(NC(=S)NCCCn2ccnc2)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 19/20 1.00
QPCTL Q9NXS2 1/20 1.00
MAOB P27338 1/20 0.74
GAA P10253 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29410444 1.00 QPCT (1.00) QPCTQPCTLMAOBGAA
Hydrochloric Acid SCHEMBL245685 0.99 QPCT (0.98) QPCTQPCTLMAOBGAA
SCHEMBL2081279 0.97 QPCT (1.00) QPCTQPCTLMAOB
SCHEMBL78461 0.93 QPCT (1.00) QPCTQPCTLMAOB
SCHEMBL76801 0.89 QPCT (1.00) QPCTQPCTLMAOBGAA
SCHEMBL76307 0.87 QPCT (1.00) QPCTQPCTL
SCHEMBL85708 0.86 QPCT (0.79) QPCTQPCTLMAOBGAA
SCHEMBL77178 0.85 QPCT (1.00) QPCTQPCTLMAOBGAA
SCHEMBL78943 0.85 QPCT (1.00) QPCTQPCTLMAOBGAA
SCHEMBL77755 0.84 QPCT (1.00) QPCTQPCTLMAOBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220384684-A1 DISPLAY DEVICE AND METHOD OF MANUFACTURING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2022-12-01 US claimed
US-20180318260-A1 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS THE SCRIPPS RESEARCH INSTITUTE 2018-11-08 US claimed
WO-2017079547-A2 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS THE SCRIPPS RESEARCH INSTITUTE (US) 2017-05-11 WO claimed
WO-2022250396-A1 DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME 삼성디스플레이 주식회사 2022-12-01 WO disclosed
US-20220384684-A1 DISPLAY DEVICE AND METHOD OF MANUFACTURING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2022-12-01 US disclosed
EP-3747438-A1 TREATING PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA - CD47 INTERACTION Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) 2020-12-09 EP disclosed
EP-3747437-A1 TREATING PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA - CD47 INTERACTION Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis (NL) 2020-12-09 EP disclosed
WO-2019022600-A1 TREATING PATHOLOGICAL CONDITIONS BY DIRECT AND INDIRECT TARGETING OF SIRPA - CD47 INTERACTION Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis (NL) 2019-01-31 WO disclosed
US-20180318260-A1 COMPOSITIONS AND METHODS FOR TREATING CYSTIC FIBROSIS THE SCRIPPS RESEARCH INSTITUTE 2018-11-08 US disclosed
EP-2082041-B1 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2018-03-14 EP disclosed
EP-2082041-B1 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2018-03-14 EP disclosed
US-20090018087-A1 Novel Inhibitors of Glutaminyl Cyclase PROBIODRUG AG (DE) 2009-01-15 US disclosed
US-20080249083-A1 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2008-10-09 US disclosed
WO-2008104580-A1 NEW USE OF GLUTAMINYL CYCLASE INHIBITORS PROBIODRUG AG (DE) 2008-09-04 WO disclosed
WO-2008034891-A2 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2008-03-27 WO disclosed
US-7304086-B2 Inhibitors of glutaminyl cyclase PROBIODRUG AG (DE) 2007-12-04 US disclosed
US-20070191366-A1 USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES PROBIODRUG AG (DE) 2007-08-16 US disclosed
EP-1713780-A2 NOVEL INHIBITORS OF GLUTAMINYL CYCLASE Probiodrug AG (DE) 2006-10-25 EP disclosed
US-20050215573-A1 Novel inhibitors of glutaminyl cyclase PROBIODRUG AG 2005-09-29 US disclosed
WO-2005075436-A2 NOVEL INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2005-08-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191366-A1 USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES GLS, QPCT, GLS2 QPCT 2/4885QPCTL 11/4885MAOB 2442/4885
US-20090018087-A1 Novel Inhibitors of Glutaminyl Cyclase GLS2, GLS, GLUL QPCT 5/4885QPCTL 83/4885MAOB 1576/4885
US-20050215573-A1 Novel inhibitors of glutaminyl cyclase GLS2, GLS, GLUL QPCT 5/4885QPCTL 83/4885MAOB 1576/4885
US-20080249083-A1 NOVEL GENES RELATED TO GLUTAMINYL CYCLASE QPCT, QPCTL, GLUL QPCT 1/4885QPCTL 2/4885MAOB 3147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.