Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 14/20 | 0.51 |
| ▸ | PLAU | P00749 | 11/20 | 0.51 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674257 | 0.91 | HPN (0.52) | HPNPLAUTMPRSS6F2LMNA | |
| SCHEMBL7663157 | 0.90 | STAT3 (0.51) | HPNPLAUTMPRSS6F2 | |
| SCHEMBL7668109 | 0.89 | MMP9 (0.55) | LMNAMMP9 | |
| SCHEMBL7674846 | 0.89 | MMP9 (0.55) | LMNAMMP9 | |
| SCHEMBL7671552 | 0.81 | STAT3 (0.52) | HPNPLAUTMPRSS6F2 | |
| SCHEMBL9088931 | 0.81 | MMP9 (0.44) | MMP9 | |
| SCHEMBL9088936 | 0.81 | MMP9 (0.44) | MMP9 | |
| SCHEMBL7674853 | 0.80 | SMN1; SMN2 (0.42) | MMP9 | |
| SCHEMBL7669327 | 0.79 | MMP9 (0.57) | LMNAMMP9 | |
| SCHEMBL7672061 | 0.79 | MMP9 (0.57) | LMNAMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |