Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 11/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 6/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | HPN | P05981 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671552 | 0.91 | STAT3 (0.52) | STAT3F2TMPRSS6PLAUHPN | |
| SCHEMBL7669305 | 0.90 | HPN (0.51) | F2TMPRSS6PLAUHPN | |
| SCHEMBL7668109 | 0.83 | MMP9 (0.55) | — | |
| SCHEMBL7674846 | 0.83 | MMP9 (0.55) | — | |
| SCHEMBL7685704 | 0.82 | CYP2C19 (0.44) | F2PRSS1 | |
| SCHEMBL7674257 | 0.81 | HPN (0.52) | F2TMPRSS6PLAUHPN | |
| SCHEMBL7671455 | 0.81 | ACLY (0.41) | STAT3F2TMPRSS6 | |
| SCHEMBL7672243 | 0.80 | ITGB3 (0.58) | F2TMPRSS6F10PLAUHPN | |
| SCHEMBL7663345 | 0.76 | ITGB3 (0.69) | F2TMPRSS6PLAUHPNITGB3 | |
| SCHEMBL7669327 | 0.73 | MMP9 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |