Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.61 |
| ▸ | HTR7 | P34969 | 3/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 6/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674067 | 0.99 | HTR1A (0.60) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7671468 | 0.99 | HTR1A (0.60) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7668732 | 0.91 | DRD2 (0.56) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7463051 | 0.90 | HTR1A (0.64) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7673363 | 0.90 | DRD2 (0.57) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7666646 | 0.90 | DRD2 (0.57) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7674736 | 0.90 | HTR1A (0.54) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7670847 | 0.89 | HTR1A (0.54) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7674793 | 0.89 | HTR1A (0.55) | HTR1ASLC6A4HTR7KCNH2DRD2 | |
| SCHEMBL7671529 | 0.89 | HTR1A (0.52) | HTR1ASLC6A4HTR7KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342498-B1 | SEROTONIN REUPTAKE INHIBITORS FOR BRAIN DISORDERS | ELI LILLY AND COMPANY | 2002-01-29 | — | — | US | disclosed |
| EP-1028958-A4 | ARYLPIPERAZINES AS SEROTONIN REUPTAKE INHIBITORS AND 5-HT1D ALPHA ANTAGONISTS | LILLY CO ELI (US) | 2001-07-18 | — | — | EP | disclosed |
| EP-1028958-A1 | ARYLPIPERAZINES AS SEROTONIN REUPTAKE INHIBITORS AND 5-HT1D ALPHA ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999020621-A1 | ARYLPIPERAZINES AS SEROTONIN REUPTAKE INHIBITORS AND 5-HT1Dα ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-29 | — | — | WO | disclosed |