Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.82 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673560 | 0.92 | TP53 (0.80) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7268471 | 0.92 | MAPT (0.78) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7699821 | 0.92 | ALDH1A1 (0.80) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7696689 | 0.88 | ALDH1A1 (0.69) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7672241 | 0.88 | MAPT (0.76) | ALDH1A1MAPTPOLBTP53KDM4E | |
| Ethylamine SCHEMBL7698776 | 0.85 | ALDH1A1 (0.65) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7694832 | 0.84 | MEN1 (0.71) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7698859 | 0.84 | ALDH1A1 (0.69) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7670400 | 0.82 | MAPT (0.67) | ALDH1A1MAPTPOLBTP53KDM4E | |
| SCHEMBL7697517 | 0.81 | ALDH1A1 (0.70) | ALDH1A1MAPTPOLBTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |