Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382734 | 0.94 | HCRTR2 (0.52) | HCRTR2LMNAGAAHTTPTGER1 | |
| SCHEMBL25333728 | 0.81 | PSEN1 (0.43) | HCRTR2KEAP1NFE2L2L3MBTL1MAPT | |
| SCHEMBL1291299 | 0.79 | PSEN1 (0.51) | HCRTR2L3MBTL1MAPTTP53PSEN1 | |
| SCHEMBL23209700 | 0.77 | MMP1 (0.46) | HCRTR2LMNAPTGER1KEAP1NFE2L2 | |
| SCHEMBL1495969 | 0.77 | TP53 (0.52) | LMNAPTGER1L3MBTL1MAPTTP53 | |
| SCHEMBL16628510 | 0.74 | PSEN1 (0.45) | LMNAKEAP1NFE2L2MAPTTP53 | |
| SCHEMBL6755023 | 0.74 | HCRTR2 (0.82) | HCRTR2LMNAGAAHTTKEAP1 | |
| SCHEMBL26159161 | 0.74 | PSEN1 (0.53) | L3MBTL1MAPTTP53PSEN1PSEN2 | |
| SCHEMBL344172 | 0.73 | TP53 (0.44) | HCRTR2LMNAHTTL3MBTL1MAPT | |
| SCHEMBL17158346 | 0.71 | C5AR1 (0.44) | HCRTR2PTGER1KEAP1NFE2L2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369221-B1 | Thiazolobenzoheterocycles, preparation and medicines containing same | AVENTIS PHARMA S.A. (FR) | 2002-04-09 | — | — | US | disclosed |