Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234273 | 0.80 | LMNA (0.41) | TP53MAPTL3MBTL1LMNAKMT2A | |
| SCHEMBL1495969 | 0.78 | TP53 (0.52) | TP53MAPTL3MBTL1LMNAKMT2A | |
| SCHEMBL5234941 | 0.74 | LMNA (0.41) | TP53MAPTL3MBTL1LMNAKMT2A | |
| SCHEMBL7670000 | 0.73 | HCRTR2 (0.52) | TP53MAPTL3MBTL1LMNAPOLB | |
| SCHEMBL17158346 | 0.72 | C5AR1 (0.44) | TP53MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL25333728 | 0.71 | PSEN1 (0.43) | TP53MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL26159161 | 0.71 | PSEN1 (0.53) | TP53MAPTL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL1291299 | 0.71 | PSEN1 (0.51) | TP53MAPTL3MBTL1HCRTR2 | |
| SCHEMBL23209700 | 0.71 | MMP1 (0.46) | TP53MAPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL10866338 | 0.70 | TSHR (0.56) | TP53MAPTL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293892-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| EP-2414358-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | ARQULE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| US-8049005-B2 | Substituted tetrahydropyrazolo-pyrido-azepine compounds | ARQULE, INC. (US) | 2011-11-01 | — | — | US | disclosed |
| WO-2010114902-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114902-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPIN COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249109-A1 | SUBSTITUTED TETRAHYDROPYRAZOLO-PYRIDO-AZEPINE COMPOUNDS | MKI67, THPO, DPYD | TP53 9/4885MAPT 2753/4885L3MBTL1 4861/4885 |
| US-20120015935-A1 | Substituted Tetrahydropyrazolo-Pyrido-Azepine Compounds | MKI67, THPO, DPYD | TP53 9/4885MAPT 2753/4885L3MBTL1 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.