Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 12/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29046728 | 0.88 | RECQL (0.64) | RECQLCA2HTR2ATAAR1CA1 | |
| SCHEMBL24670084 | 0.82 | CA2 (0.52) | RECQLCA2CA1CA9CA12 | |
| SCHEMBL3140888 | 0.80 | TAAR1 (0.43) | CA2HTR2ATAAR1CA1CA9 | |
| SCHEMBL660034 | 0.80 | RECQL (0.50) | RECQLCA2TAAR1CA1CA9 | |
| SCHEMBL1793990 | 0.79 | CA2 (0.72) | RECQLCA2HTR2ACA1CA9 | |
| SCHEMBL29270369 | 0.78 | TAAR1 (0.42) | CA2HTR2ATAAR1CA1CA9 | |
| SCHEMBL4061411 | 0.78 | CA2 (0.70) | RECQLCA2HTR2ACA1CA9 | |
| SCHEMBL5515360 | 0.76 | HRH1 (0.52) | RECQLCA2CA1SMN1; SMN2CA7 | |
| SCHEMBL18063459 | 0.76 | CA2 (0.53) | CA2HTR2ATAAR1CA1CA9 | |
| SCHEMBL2093098 | 0.76 | CA1 (0.58) | CA2TAAR1CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951170-A2 | FLAP MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |
| US-6500865-B1 | POTENTIATING GLUTAMATE RECEPTORS BY ADMINISTERING N-1-(4-(4-(2-METHANESULFONAMIDO ETHYL)PHENY)PHENYL)ETHYL 2-PROPANE SULFONAMIDE FOR LEARNING ENHANCEMENT AND PROPHYLAXIS OF NEURODEGENERATIVE DISORDERS, PSYCHOSIS OR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-12-31 | — | — | US | disclosed |
| WO-2000006083-A2 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |