Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608518 | 0.87 | RECQL (0.67) | CA2CA1CA12CA4CA6 | |
| SCHEMBL660034 | 0.82 | RECQL (0.50) | CA2CA1CA12CA6CA5A | |
| SCHEMBL7670239 | 0.82 | RECQL (0.50) | CA2CA1CA12CA4CA7 | |
| SCHEMBL1793990 | 0.81 | CA2 (0.72) | CA2CA1CA12CA5ACA7 | |
| SCHEMBL4061411 | 0.79 | CA2 (0.70) | CA2CA1CA12CA5ACA7 | |
| SCHEMBL5515360 | 0.78 | HRH1 (0.52) | CA2CA1CA5ACA7CA5B | |
| SCHEMBL2093098 | 0.77 | CA1 (0.58) | CA2CA1CA12CA4CA5A | |
| SCHEMBL27885351 | 0.77 | RECQL (0.42) | CA2CA1CA12CA4CA6 | |
| SCHEMBL24670427 | 0.77 | RECQL (0.39) | CA2CA1CA12CA4CA6 | |
| SCHEMBL6312084 | 0.77 | HRH3 (0.58) | CA2CA1CA12CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |