Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673174 | 0.93 | HIF1A (0.39) | TSHRHIF1AFAAHTRPV1CYP1A2 | |
| SCHEMBL7673096 | 0.84 | CYP1A2 (0.36) | TSHRHIF1ACYP1A2MAPK1CA12 | |
| SCHEMBL15015862 | 0.81 | CYP1A2 (0.43) | TSHRCYP1A2MAPK1CA12CA1 | |
| SCHEMBL10706034 | 0.78 | ALDH1A1 (0.42) | TSHRCYP1A2MAPK1CA12CA1 | |
| SCHEMBL15015968 | 0.75 | CYP1A2 (0.43) | TSHRCYP1A2MAPK1CA12CA1 | |
| SCHEMBL7678665 | 0.75 | TSHR (0.50) | TSHRHIF1AFAAHTRPV1MAPK1 | |
| SCHEMBL29956786 | 0.74 | ALDH1A1 (0.35) | TSHRCYP1A2MAPK1CA12CA1 | |
| SCHEMBL1409410 | 0.74 | — | — | |
| SCHEMBL2231055 | 0.74 | — | — | |
| SCHEMBL13509722 | 0.74 | LMNA (0.46) | TSHRCYP1A2MAPK1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | claimed |
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | disclosed |