Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12880767 | 0.86 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA7GRM2RIPK1 | |
| SCHEMBL27326669 | 0.78 | CHRNB2 (0.71) | CHRNB2CHRNA4CHRNA7RIPK1LMNA | |
| SCHEMBL30632262 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7RIPK1LMNA | |
| SCHEMBL6629548 | 0.77 | ALDH1A1 (0.54) | LMNAALDH1A1KDM4E | |
| SCHEMBL10028665 | 0.77 | CHRNB2 (0.85) | CHRNB2CHRNA4CHRNA7RIPK1LMNA | |
| SCHEMBL3460939 | 0.77 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7RIPK1LMNA | |
| SCHEMBL6749666 | 0.76 | CHRNB2 (0.50) | CHRNB2CHRNA4GRM2RIPK1LMNA | |
| SCHEMBL22928701 | 0.76 | CHRNB2 (0.75) | CHRNB2CHRNA4CHRNA7RIPK1LMNA | |
| SCHEMBL12089140 | 0.75 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA7GRM2RIPK1 | |
| SCHEMBL29642739 | 0.74 | ALDH1A1 (0.62) | LMNAALDH1A1NAMPTKDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458783-B1 | INHIBITION OF FARNESYL TRANSFERASE, WHICH IS AN ENZYME INVOLVED IN RAS ONCOGENE EXPRESSION, IS EFFECTED BY COMPOUNDS OF THE FORMULAS OF BENODIAZEPINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-2001081322-A1 | NON-IMIDAZOLE BENZODIAZEPINE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |