Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 8/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13169478 | 0.82 | PLK4 (0.70) | IKBKBMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL3701102 | 0.82 | PLK4 (0.70) | IKBKBMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL7476936 | 0.75 | IKBKB (0.72) | IKBKBMEN1KMT2ACDK4PIK3CA | |
| SCHEMBL13169413 | 0.74 | PLK4 (0.79) | PLK4 | |
| SCHEMBL3693031 | 0.74 | TGM2 (0.56) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL13169463 | 0.74 | TGM2 (0.56) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL3693261 | 0.74 | MEN1 (0.47) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL13169475 | 0.74 | JAK1 (0.47) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL13169420 | 0.74 | JAK1 (0.47) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL13169430 | 0.74 | PLK4 (0.76) | IKBKBPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337335-B1 | ENZYME INHIBITORS FOR AUTOIMMUNE DISEASES, TRANSPLANT REJECTION, GRANT VERSUS HOST DISEASE, HYPERPROLIFERATIVE DISORDERS AND DISEASES IN WHICH CELLS RECEIVE PRO-INFLAMMATORY SIGNALS. | CELLTECH THERAPEUTICS LIMITED (GB) | 2002-01-08 | — | — | US | disclosed |
| US-6048866-A | Substituted 2-anilinopryimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |