Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670553 | 1.00 | HTT (0.45) | HTTSMN1; SMN2LMNAEGFRALDH1A1 | |
| SCHEMBL6972201 | 0.80 | ITGB1 (0.66) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL6972192 | 0.80 | ITGB1 (0.66) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL1467988 | 0.68 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2LMNAEGFRALDH1A1 | |
| SCHEMBL24003686 | 0.68 | P2RX7 (0.64) | SMN1; SMN2LMNAEGFRALDH1A1NPC1 | |
| SCHEMBL6977318 | 0.68 | ITGB1 (0.67) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL6977320 | 0.68 | ITGB1 (0.67) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL3675077 | 0.68 | GFER (0.57) | HTTSMN1; SMN2LMNAEGFRALDH1A1 | |
| SCHEMBL6992077 | 0.67 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2LMNAEGFRALDH1A1 | |
| SCHEMBL27476499 | 0.67 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2LMNAEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465471-B1 | INHIBIT BINDING OF ALPHA 4 INTEGRINS TO THEIR LIGANDS THUS THEY ARE OF USE IN PROPHYLAXIS AND TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS | CELLTECH THERAPEUTICS LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |