Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045708 | 0.84 | ALDH1A1 (0.58) | ALDH1A1CYP19A1POLBAKR1B1 | |
| SCHEMBL15506139 | 0.83 | CYP2A6 (0.45) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL202404 | 0.82 | ALDH1A1 (0.61) | ALDH1A1GRM5TTRALB | |
| SCHEMBL15834511 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL4695771 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL4693657 | 0.81 | GRM5 (0.41) | ALDH1A1MAOAMAOBCYP19A1GRM5 | |
| SCHEMBL29413295 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL6683961 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL16481540 | 0.80 | PTGS2 (0.44) | ALDH1A1MAOAMAOBRAB9ACYP19A1 | |
| SCHEMBL509576 | 0.80 | ALDH1A1 (0.58) | ALDH1A1GRM5TTRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| CN-1284075-A | Novel compounds having CGMP-PDE inhibitory effect | MOCHIDA PHARM CO LTD (JP) | 2001-02-14 | — | — | CN | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |