Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674292 | 0.91 | ENPP1 (0.54) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 | |
| SCHEMBL7667916 | 0.90 | F2 (0.52) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 | |
| SCHEMBL5092484 | 0.89 | MEN1 (0.55) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 | |
| SCHEMBL7667880 | 0.89 | LMNA (0.54) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 | |
| SCHEMBL7669959 | 0.89 | KDM4E (0.53) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7670379 | 0.88 | ALDH1A1 (0.50) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 | |
| SCHEMBL7671606 | 0.88 | KDM4E (0.52) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7673461 | 0.88 | KDM4E (0.52) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7669245 | 0.88 | KDM4E (0.52) | LMNAALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7671859 | 0.88 | PRMT1 (0.56) | LMNAALDH1A1F2TMPRSS6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |