Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30469481 | 0.85 | GRM5 (0.69) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL4562089 | 0.85 | GRM5 (0.69) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL30469478 | 0.85 | GRM5 (0.69) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL7132620 | 0.81 | GRM5 (0.59) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL23704113 | 0.79 | ACHE (0.57) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL4946180 | 0.79 | GRM5 (0.62) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL28490028 | 0.77 | GRM5 (0.55) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL29769643 | 0.77 | GRM5 (0.55) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL28153461 | 0.77 | GRM5 (0.55) | GRM5ACHECA12CA1CA2 | |
| SCHEMBL25490060 | 0.77 | GRM5 (0.55) | GRM5ACHECA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | F.HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, GRM1 | GRM5 1/4885ACHE 2615/4885CA12 4087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.