Pyridine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NAPRT	Q6XQN6	4/20	0.50

▸	TSHR	P16473	1/20	0.50

▸	TDP1	Q9NUW8	1/20	0.50

▸	FFAR3	O14843	1/20	0.39

▸	LCK	P06239	1/20	0.39

▸	FYN	P06241	1/20	0.39

▸	KMT2A	Q03164	2/20	0.36

▸	MEN1	O00255	1/20	0.36

▸	ALDH1A1	P00352	4/20	0.34

▸	APP	P05067	1/20	0.34

▸	GAA	P10253	1/20	0.34

▸	HCAR3	P49019	1/20	0.34

▸	HCAR2	Q8TDS4	1/20	0.34

▸	F7	P08709	1/20	0.33

▸	F3	P13726	1/20	0.33

▸	SARM1	Q6SZW1	1/20	0.33

▸	SIRT2	Q8IXJ6	1/20	0.33

▸	SIRT6	Q8N6T7	1/20	0.33

▸	SIRT1	Q96EB6	1/20	0.33

▸	SIRT3	Q9NTG7	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Pyridine SCHEMBL2007426	0.97	NAPRT (0.53)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL27534868	0.94	NAPRT (0.56)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL9246176	0.94	NAPRT (0.56)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL10380397	0.94	NAPRT (0.56)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL8899457	0.94	NAPRT (0.56)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL15571878	0.92	NAPRT (0.53)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL4881283	0.92	NAPRT (0.53)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL15571092	0.92	NAPRT (0.53)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL10977701	0.91	NAPRT (0.60)	NAPRTTSHRTDP1FFAR3LCK
Pyridine SCHEMBL11125163	0.91	NAPRT (0.60)	NAPRTTSHRTDP1FFAR3LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20140179875-A1	SULFURIZATION REAGENTS ON SOLID SUPPORTS	GIRINDUS AMERICA, INC. (US)	2014-06-26	—	—	US	disclosed
US-20120071640-A1	Sulfurizing reagents and their use for oligonucleotides synthesis	GIRINDUS AMERICA, INC. (US)	2012-03-22	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120071640-A1	Sulfurizing reagents and their use for oligonucleotides synthesis	RRM1, SRRT, NSUN2	NAPRT 540/4885TSHR 1504/4885TDP1 2651/4885
US-20140179875-A1	SULFURIZATION REAGENTS ON SOLID SUPPORTS	OR10J3, RPS8, NSUN2	NAPRT 1794/4885TSHR 389/4885TDP1 4259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.