RPS8

Small ribosomal subunit protein eS8 · P62241 · RPS8 on Sugi Atlas →

3,484 patent compounds predicted against RPS8, 1,791 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13625506	0.44	7/20
SCHEMBL5500526	0.41	4/20
SCHEMBL5500532	0.41	4/20
SCHEMBL5503310	0.41	4/20
SCHEMBL11844361	0.35	4/20
SCHEMBL2000440	0.39	3/20
SCHEMBL8219903	0.36	3/20
SCHEMBL11627320	0.34	3/20
SCHEMBL6394396	0.47	2/20
N-Methylpiperidine (SCHEMBL11205373)	0.42	2/20
Bicarbonate (SCHEMBL9058396)	0.42	2/20
SCHEMBL4960293	0.41	2/20
SCHEMBL4961968	0.40	2/20
SCHEMBL6686992	0.40	2/20
SCHEMBL9429122	0.38	2/20
Chloramphenicol (SCHEMBL10796001)	1.00	1/20
Geneticin (SCHEMBL15596)	0.93	1/20
Geneticin (SCHEMBL5006573)	0.93	1/20
Geneticin (SCHEMBL9920496)	0.93	1/20
Chloramphenicol (SCHEMBL16111)	0.90	1/20

Clinical trials — most relevant to RPS8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes	PHASE4	UNKNOWN
Tacrolimus Treatment for Refractory PRCA	PHASE4	UNKNOWN
Sirolimus Treatment for Refractory PRCA	PHASE4	COMPLETED
Proteome-based Personalized Immunotherapy of Glioblastoma	PHASE2/PHASE3	UNKNOWN
Proteome-based Immunotherapy of Lung Cancer Brain Metastases	PHASE2/PHASE3	UNKNOWN
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
Ibrutinib, Fludarabine Phosphate, Cyclophosphamide, and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia	PHASE2	ACTIVE_NOT_RECRUITING
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia	PHASE1	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS)	PHASE1	RECRUITING
Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	PHASE1	WITHDRAWN
Role of RPL8 Protein Alterations in High-grade Serous Ovarian Carcinoma	nan	RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
RibOSE - Glucose and Resistance Exercise Training	nan	COMPLETED
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children	nan	COMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RPS8 binder may also engage these)

Protein	Name	Similarity
Q5E958	—	1.000	Q5E958 →
P62242	—	1.000	P62242 →
Q4R6P8	—	1.000	Q4R6P8 →
P62243	—	1.000	P62243 →
G1TJW1	—	1.000	G1TJW1 →
B1VAE4	—	0.991	B1VAE4 →
A9BHA1	—	0.985	A9BHA1 →
Q7VQE4	—	0.984	Q7VQE4 →
Q30Z46	—	0.984	Q30Z46 →
A0LIJ4	—	0.984	A0LIJ4 →
A9WH70	—	0.984	A9WH70 →
A6QCQ2	—	0.984	A6QCQ2 →
B6IRR0	—	0.983	B6IRR0 →
Q8M9U8	—	0.983	Q8M9U8 →
A9KD27	—	0.983	A9KD27 →
B6J259	—	0.983	B6J259 →
Q83ES0	—	0.982	Q83ES0 →
A9NAM8	—	0.982	A9NAM8 →
B8FET1	—	0.982	B8FET1 →
Q1KVT8	—	0.982	Q1KVT8 →
Q0BYB8	—	0.982	Q0BYB8 →
Q19VA9	—	0.982	Q19VA9 →
A7NR59	—	0.982	A7NR59 →
Q8A480	—	0.981	Q8A480 →
O83223	—	0.981	O83223 →
Q8MLY8	—	0.981	Q8MLY8 →
P56026	—	0.981	P56026 →
Q32RN7	—	0.981	Q32RN7 →
A0L5X7	—	0.981	A0L5X7 →
B2S2E0	—	0.981	B2S2E0 →