Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28290479 | 0.81 | ALDH1A1 (0.33) | ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL525712 | 0.80 | — | — | |
| SCHEMBL482463 | 0.80 | HPGD (0.39) | ALDH1A1HPGD | |
| SCHEMBL11171654 | 0.77 | AOC3 (0.32) | — | |
| SCHEMBL27495269 | 0.77 | AOC3 (0.32) | — | |
| SCHEMBL10397204 | 0.77 | AOC3 (0.32) | — | |
| SCHEMBL10397205 | 0.77 | AOC3 (0.32) | — | |
| SCHEMBL6727394 | 0.77 | — | — | |
| SCHEMBL6238419 | 0.76 | JAK2 (0.33) | ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL1984410 | 0.76 | MAOB (0.35) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8618307-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20130245025-A1 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| EP-2619200-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| US-8383670-B2 | Trisubstituted thiophenes that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2477982-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2012040511-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071516-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-03-22 | — | — | US | disclosed |
| US-20110212970-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| WO-2011034962-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-03-24 | — | — | WO | disclosed |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-03-17 | — | — | US | disclosed |
| US-7906553-B2 | Substituted thiophene modulators of intracellular calcium | CALCIMEDICA, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100261725-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2010-10-14 | — | — | US | disclosed |
| EP-0830638-B1 | PRE-DYES AND COMPOSITIONS COMPRISING THEM | KIMBERLY CLARK CO (US) | 2000-08-23 | — | — | EP | disclosed |
| US-6063551-A | A LEUCO DYE ASSOCIATED WITH A RADIATION TRANSORBER WHERE THE RADIATION TRANSORBER COMPRISES A WAVELENGTH-SELECTIVE SENSITIZER COVALENTLY BONDED TO A REACTIVE SPECIES-GENERATING PHOTOREACTOR; PHTHALOYLGLYCINE; 4-(4-HYDROXYPHENYL)BUT-2-ONE | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-5837429-A | DYE COVALENTLY BOUND TO RADIATION TRANSORBER THAT IS COLORLESS AND WILL FORM COLOR WHEN IRRADIATED | KIMBERLY-CLARK WORLDWIDE (US) | 1998-11-17 | — | — | US | disclosed |
| US-5786132-A | Pre-dyes, mutable dye compositions, and methods of developing a color | KIMBERLY-CLARK CORPORATION (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0830638-A1 | NOVEL PRE-DYES | Kimberly-Clark Worldwide, Inc. (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996039646-A1 | NOVEL PRE-DYES | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261725-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
| US-20140051711-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
| US-20110212970-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
| US-20130245025-A1 | Compounds that modulate intracellular calcium | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
| US-20120071516-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
| US-20110065724-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | CTSS 1220/4885CTSK 1533/4885CTSL 2660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.