Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669588 | 0.92 | KDM4E (0.59) | ALDH1A1LMNAPRMT1KDM4ETRPV1 | |
| SCHEMBL7669110 | 0.91 | KDM4E (0.58) | ALDH1A1LMNAPRMT1KDM4ETRPV1 | |
| SCHEMBL7667917 | 0.91 | KDM4E (0.58) | ALDH1A1LMNAPRMT1KDM4ETRPV1 | |
| SCHEMBL7667904 | 0.91 | KDM4E (0.58) | ALDH1A1LMNAPRMT1KDM4ETRPV1 | |
| SCHEMBL7663470 | 0.90 | LMNA (0.62) | ALDH1A1LMNAPRMT1MAPK1SMN1; SMN2 | |
| SCHEMBL5099330 | 0.85 | MEN1 (0.62) | ALDH1A1LMNAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL7665894 | 0.84 | LMNA (0.60) | ALDH1A1LMNAPRMT1KMT2AMEN1 | |
| SCHEMBL7669714 | 0.84 | ALDH1A1 (0.56) | ALDH1A1LMNAPRMT1KMT2ASMN1; SMN2 | |
| SCHEMBL7674292 | 0.84 | ENPP1 (0.54) | ALDH1A1LMNAENPP1PRMT1KDM4E | |
| SCHEMBL7671620 | 0.83 | LMNA (0.59) | ALDH1A1LMNAPRMT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |