Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.70 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.70 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.70 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.70 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15386010 | 0.83 | GABRG2 (0.75) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7403627 | 0.83 | GABRG2 (0.49) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2461269 | 0.82 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7672131 | 0.82 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL19575097 | 0.81 | GABRG2 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7667586 | 0.80 | GABRA1 (0.66) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7663055 | 0.80 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL12068741 | 0.79 | GABRA1 (0.64) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2655468 | 0.79 | GABRA1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL19575090 | 0.78 | GABRA1 (0.63) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | claimed |
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | disclosed |