Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.77 |
| ▸ | MMP2 | P08253 | 6/20 | 0.77 |
| ▸ | MMP1 | P03956 | 6/20 | 0.77 |
| ▸ | MMP3 | P08254 | 3/20 | 0.77 |
| ▸ | MMP9 | P14780 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691597 | 1.00 | MMP13 (0.77) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6693892 | 0.87 | MMP13 (1.00) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6692001 | 0.84 | MMP13 (0.68) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL4293140 | 0.80 | MMP13 (0.58) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL4293133 | 0.80 | MMP13 (0.58) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6694627 | 0.78 | MMP13 (0.68) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6697906 | 0.78 | MMP13 (0.69) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6690771 | 0.77 | MMP13 (1.00) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6693840 | 0.76 | MMP13 (0.81) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL7673136 | 0.75 | MMP13 (0.80) | MMP13MMP2MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458822-B2 | (4R)-1-(4-(4-FLUOROPHENOXY)BENZYL)-2-OXO-IMIDAZOLIDINE-4 -CARBOXYLIC ACID HYDROXYAMIDE, FOR EXAMPLE; TREATING VARIOUS DISEASES INCLUDING OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CANCER, OSTEOPOROSIS, STROKES | PFIZER INC. | 2002-10-01 | — | — | US | disclosed |