SCHEMBL7672143

SCHEMBL7672143

CCCc1cccc2c1CN(C(CC(=O)O)C(N)=O)C2=O

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
ALDH1A1 P00352 3/20 0.36
POLB P06746 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MAPT P10636 4/20 0.36
ALOX15 P16050 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KDM4E B2RXH2 1/20 0.36
THRB P10828 1/20 0.34
SDCBP O00560 1/20 0.33
SDC2 P34741 1/20 0.33
STAT3 P40763 1/20 0.33
GAA P10253 1/20 0.33
CMA1 P23946 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7676753 0.93 MEN1 (0.38) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL7678935 0.92 MEN1 (0.43) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL7679921 0.91 ALOX15 (0.43) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL7678757 0.89 ALDH1A1 (0.41) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL7676710 0.86 ALOX15 (0.41) MEN1KMT2AALDH1A1MAPTALOX15
SCHEMBL7679533 0.84 ALOX15 (0.41) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL7671115 0.83 MAPT (0.41) MEN1KMT2AALDH1A1POLBL3MBTL1
SCHEMBL7671030 0.83 KDM4E (0.39) ALDH1A1POLBALOX15KDM4E
SCHEMBL7675268 0.82 ALOX15 (0.44) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL7680451 0.82 ALOX15 (0.45) MEN1KMT2AALDH1A1POLBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6495417-B1 Method for increasing tolerance of contact extension alignment in COB DRAM UNITED MICROELECTRONICS CORPS. (TW) 2002-12-17 US disclosed
US-6380239-B1 FOR THERAPY OF ARTHRITIS, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, REPERFUSION INJURY, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, ULCERATIVE COLITIS, SYSTEMIC LUPUS ERYTHREMATOSIS, SCLERODERMA, APHTHOUS ULCERS, ASTHMA CELGENE CORPORATION 2002-04-30 US disclosed
EP-1163219-A1 SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS CELGENE CORPORATION (US) 2001-12-19 EP disclosed
WO-2000055134-A1 SUBSTITUTED 1-OXO- AND 1,3-DIOXOISOINDOLINES AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATORY CYTOKINE LEVELS CELGENE CORPORATION (US) 2000-09-21 WO disclosed