Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.34 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683149 | 0.88 | OPRD1 (0.68) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7668256 | 0.84 | OPRD1 (0.63) | OPRD1OPRK1OPRM1ALDH1A1SOAT1 | |
| SCHEMBL7667730 | 0.83 | OPRD1 (0.68) | OPRD1OPRK1OPRM1ALDH1A1SOAT1 | |
| SCHEMBL7667741 | 0.81 | OPRD1 (0.69) | OPRD1OPRK1OPRM1ALDH1A1SOAT1 | |
| SCHEMBL7667354 | 0.81 | OPRD1 (0.59) | OPRD1OPRK1OPRM1ALDH1A1SOAT1 | |
| SCHEMBL7666977 | 0.73 | OPRD1 (0.73) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8124466 | 0.73 | OPRD1 (0.67) | OPRD1OPRK1OPRM1KCNH2 | |
| SCHEMBL8134558 | 0.72 | OPRD1 (0.81) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8133582 | 0.71 | OPRD1 (0.65) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8135859 | 0.71 | OPRD1 (0.65) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |