Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.37 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667730 | 0.90 | OPRD1 (0.68) | OPRD1OPRK1OPRM1HDAC3HDAC1 | |
| SCHEMBL7667741 | 0.88 | OPRD1 (0.69) | OPRD1OPRK1OPRM1HDAC3HDAC1 | |
| SCHEMBL7667354 | 0.88 | OPRD1 (0.59) | OPRD1OPRK1OPRM1SOAT1LMNA | |
| SCHEMBL7683691 | 0.85 | OPRD1 (0.83) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7672193 | 0.84 | OPRD1 (0.56) | OPRD1OPRK1OPRM1SOAT1KMT2A | |
| SCHEMBL7671714 | 0.82 | LMNA (0.55) | OPRD1OPRK1OPRM1LMNAKMT2A | |
| SCHEMBL8124466 | 0.80 | OPRD1 (0.67) | OPRD1OPRK1OPRM1HDAC6 | |
| SCHEMBL7672971 | 0.80 | OPRK1 (0.78) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8134558 | 0.79 | OPRD1 (0.81) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8133582 | 0.79 | OPRD1 (0.65) | OPRD1OPRK1OPRM1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |