Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 17/20 | 0.54 |
| ▸ | NPC1 | O15118 | 16/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 4/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627377 | 0.86 | RAB9A (0.56) | RAB9ANPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL7626917 | 0.84 | NPC1 (0.49) | RAB9ANPC1ALDH1A1LMNARXFP1 | |
| SCHEMBL7623677 | 0.83 | RAB9A (0.50) | RAB9ANPC1ALDH1A1LMNACASP3 | |
| SCHEMBL7647123 | 0.82 | PLAU (0.54) | RAB9ANPC1ALDH1A1LMNACASP3 | |
| SCHEMBL7626085 | 0.81 | LCK (0.49) | RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL7632422 | 0.80 | RAB9A (0.53) | RAB9ANPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL7631048 | 0.79 | LCK (0.61) | ALDH1A1 | |
| SCHEMBL6058291 | 0.79 | HTT (0.61) | RAB9ANPC1ALDH1A1LMNACASP3 | |
| SCHEMBL7626952 | 0.77 | RAB9A (0.55) | RAB9ANPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL7631046 | 0.77 | LCK (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-A4 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1037632-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999024035-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |