Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624309 | 0.89 | ALDH1A1 (0.52) | LCKALDH1A1 | |
| SCHEMBL7631048 | 0.88 | LCK (0.61) | LCKALDH1A1 | |
| SCHEMBL7631046 | 0.83 | LCK (0.70) | LCK | |
| SCHEMBL7628467 | 0.83 | LCK (0.67) | LCK | |
| SCHEMBL6058332 | 0.82 | LCK (0.63) | LCK | |
| SCHEMBL7626181 | 0.82 | LCK (0.62) | LCK | |
| SCHEMBL7672583 | 0.81 | RAB9A (0.54) | NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7623796 | 0.80 | LCK (0.52) | LCK | |
| SCHEMBL7629155 | 0.80 | LCK (0.47) | LCKNPC1RAB9A | |
| SCHEMBL7627306 | 0.80 | ALDH1A1 (0.49) | LCKNPC1RAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037632-A4 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-1037632-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999024035-A1 | BENZOTHIAZOLE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |