Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8536795 | 0.91 | CYP19A1 (0.54) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL7167409 | 0.90 | CYP19A1 (0.53) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL27582477 | 0.89 | CYP19A1 (0.52) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL8535642 | 0.84 | CYP19A1 (0.58) | CYP19A1HTR1ASIGMAR1ACHEALDH1A1 | |
| SCHEMBL8667349 | 0.84 | METAP1 (0.54) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL6689014 | 0.83 | CYP19A1 (0.61) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL14061950 | 0.81 | CYP26A1 (0.67) | CYP19A1CYP26A1 | |
| SCHEMBL8534761 | 0.81 | ALDH1A1 (0.52) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL8536658 | 0.80 | HTR2C (0.50) | CYP19A1HTR1ASIGMAR1ACHEHTR2C | |
| SCHEMBL6694407 | 0.80 | CYP19A1 (0.61) | CYP19A1HTR1ASIGMAR1ACHEHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101450912-B | Tetrahydronaphthalene substituted benzoic acid derivatives | KBP BIOSCIENCES CO LTD | 2012-05-30 | — | — | CN | disclosed |
| CN-101450912-A | Tetrahydronaphthalene substituted benzoic acid derivates | SHANDONG XUANZHU MEDICAL SCI T (CN) | 2009-06-10 | — | — | CN | disclosed |
| EP-1231938-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001034137-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |
| US-5847159-A | 1- ω-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0825180-A1 | 1-OMEGA-(3,4-DIHYDRO-2-NAPHTHALENYL)ALKYL] CYCLIC AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |
| US-5288752-A | Brain disorders | SUNTORY LIMITED (JP) | 1994-02-22 | — | — | US | disclosed |
| EP-0322248-B1 | COMPOUNDS EFFECTIVE AGAINST CEREBRAL INSUFFICIENCY | SUNTORY LIMITED (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5179092-A | Cognition activators | SUNTORY LIMITED (JP) | 1993-01-12 | — | — | US | disclosed |
| EP-0322248-A2 | Compounds effective against cerebral insufficiency | SUNTORY LIMITED (JP) | 1989-06-28 | — | — | EP | disclosed |