Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TNKS | O95271 | 2/20 | 0.56 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27925475 | 0.88 | TNKS2 (0.72) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2821455 | 0.88 | TNKS2 (0.72) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27925494 | 0.88 | TNKS2 (0.72) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7674927 | 0.86 | TNKS2 (1.00) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL29913510 | 0.86 | TNKS2 (1.00) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL30257239 | 0.79 | ALDH1A1 (1.00) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7665294 | 0.79 | ALDH1A1 (1.00) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7673041 | 0.77 | TNKS2 (0.64) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL31338442 | 0.77 | TNKS2 (0.64) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7667617 | 0.77 | TNKS2 (0.64) | TNKS2ALDH1A1KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479499-B1 | INHIBITORS OF TUBULIN POLYMERIZATION | NATIONAL SCIENCE COUNCIL (TW) | 2002-11-12 | — | — | US | disclosed |