⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25137956 | 0.86 | CTSK (0.47) | — | |
| SCHEMBL28101675 | 0.84 | ADH1B (0.44) | — | |
| SCHEMBL7675770 | 0.83 | ADH1B (0.39) | — | |
| SCHEMBL20613230 | 0.82 | ADH1B (0.47) | — | |
| SCHEMBL29326874 | 0.82 | ADH1B (0.47) | — | |
| SCHEMBL13351307 | 0.81 | — | — | |
| SCHEMBL7675794 | 0.79 | ADH1B (0.39) | — | |
| SCHEMBL3839686 | 0.79 | ADH1B (0.43) | — | |
| SCHEMBL7670245 | 0.79 | — | — | |
| SCHEMBL17206996 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | claimed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| CN-101711252-A | heterocyclic spiro-compounds | NOVARTIS AG | 2010-05-19 | — | — | CN | disclosed |
| CN-101184757-A | Heterocyclic spiro compounds as aldosterone synthase inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2008-05-21 | — | — | CN | disclosed |
| CN-101184760-A | Heterocyclic spiro-compounds | SPEEDEL EXPERIMENTA AG (CH) | 2008-05-21 | — | — | CN | disclosed |
| CN-1956987-A | Heterocyclic compounds and their use as aldosterone synthase inhibitors | SPEEDEL EXPERIMENTA AG (CH) | 2007-05-02 | — | — | CN | disclosed |
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | disclosed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |