Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830289 | 0.87 | MAPK1 (0.72) | MAPK1MAPTKDM4EL3MBTL1CA1 | |
| SCHEMBL4398996 | 0.85 | MAPK1 (0.74) | MAPK1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL28650145 | 0.85 | MAPK1 (0.74) | MAPK1KDM4EL3MBTL1MEN1AHR | |
| SCHEMBL31314624 | 0.85 | MAPK1 (0.74) | MAPK1KDM4EL3MBTL1MEN1AHR | |
| SCHEMBL27726456 | 0.84 | MAPK1 (0.51) | MAPK1MAPTKDM4EL3MBTL1CA1 | |
| SCHEMBL29508473 | 0.84 | MAPK1 (1.00) | MAPK1MAPTKDM4EL3MBTL1CA1 | |
| SCHEMBL69747 | 0.84 | MAPK1 (1.00) | MAPK1MAPTKDM4EL3MBTL1CA1 | |
| SCHEMBL9180143 | 0.84 | ALDH1A1 (0.56) | MAPK1MAPTKDM4EL3MBTL1MEN1 | |
| SCHEMBL19555959 | 0.84 | MAPK1 (0.68) | MAPK1KDM4EL3MBTL1MEN1AHR | |
| SCHEMBL30112031 | 0.84 | MAPK1 (0.68) | MAPK1KDM4EL3MBTL1MEN1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1103770-C | Quinoxalinediones | PFIZER RES AND DEV CO N V S A (IE) | 2003-03-26 | — | — | CN | disclosed |
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| CN-1213369-A | Quinoxalinedione compound | PFIZER RES & DEV (IE) | 1999-04-07 | — | — | CN | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |