Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10523974 | 0.82 | NPC1 (0.60) | ALDH1A1LMNANPC1RAB9AHPGD | |
| SCHEMBL7674053 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4ECRBNLMNANPC1 | |
| SCHEMBL25143774 | 0.78 | DDB1 (0.47) | ALDH1A1CRBNLMNANPC1RAB9A | |
| SCHEMBL29392153 | 0.77 | CHEK1 (0.56) | ALDH1A1KDM4ECRBN | |
| SCHEMBL7673369 | 0.77 | CHEK1 (0.56) | ALDH1A1KDM4ECRBN | |
| SCHEMBL22720116 | 0.76 | ALDH1A1 (0.66) | ALDH1A1KDM4ECRBNLMNAPKM | |
| SCHEMBL13161898 | 0.76 | ALDH1A1 (0.61) | ALDH1A1KDM4ECRBNLMNAPKM | |
| SCHEMBL31267432 | 0.76 | ALDH1A1 (0.59) | ALDH1A1KDM4ECRBNLMNAPKM | |
| SCHEMBL2060435 | 0.76 | CRBN (0.56) | ALDH1A1KDM4ECRBNLMNAPKM | |
| SCHEMBL11056410 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4ECRBNLMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045437-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-06-02 | — | — | US | disclosed |
| US-9006239-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-04-14 | — | — | US | disclosed |
| US-8710064-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2014-04-29 | — | — | US | disclosed |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2014-01-16 | — | — | US | disclosed |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2013-11-21 | — | — | US | disclosed |
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | CHINA MEDICAL UNIVERSITY (TW) | 2013-04-25 | — | — | US | disclosed |
| US-6479499-B1 | INHIBITORS OF TUBULIN POLYMERIZATION | NATIONAL SCIENCE COUNCIL (TW) | 2002-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | AQP4, KRAS, RB1 | ALDH1A1 755/4885KDM4E 1135/4885CRBN 350/4885 |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, NFE2, NR2E1 | ALDH1A1 1847/4885KDM4E 51/4885CRBN 1092/4885 |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, RB1, NR2E1 | ALDH1A1 2164/4885KDM4E 91/4885CRBN 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.