Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673613 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDL3MBTL1CYP2D6 | |
| SCHEMBL6550497 | 0.90 | POLB (0.45) | ALDH1A1KDM4EHPGDL3MBTL1TSHR | |
| SCHEMBL6550490 | 0.90 | POLB (0.45) | ALDH1A1KDM4EHPGDL3MBTL1TSHR | |
| Hydrochloric Acid SCHEMBL6548749 | 0.85 | TSHR (0.46) | ALDH1A1KDM4EHPGDL3MBTL1CYP2D6 | |
| Hydrochloric Acid SCHEMBL6548051 | 0.85 | TSHR (0.46) | ALDH1A1KDM4EHPGDL3MBTL1CYP2D6 | |
| SCHEMBL7683845 | 0.82 | MEN1 (0.49) | ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL7683841 | 0.82 | MEN1 (0.49) | ALDH1A1L3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6548838 | 0.77 | MAPT (0.40) | ALDH1A1KDM4EHPGDL3MBTL1CYP2D6 | |
| SCHEMBL6550737 | 0.75 | NFE2L2 (0.40) | ALDH1A1KDM4EHPGDCYP2D6LMNA | |
| SCHEMBL6550733 | 0.75 | NFE2L2 (0.40) | ALDH1A1KDM4EHPGDCYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500823-B1 | ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES | N-GENE RESEARCH LABORATORIES, INC. | 2002-12-31 | — | — | US | claimed |