Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.78 |
| ▸ | MMP2 | P08253 | 9/20 | 0.70 |
| ▸ | TACR1 | P25103 | 4/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667544 | 1.00 | MMP9 (0.78) | MMP9MMP2TACR1KCNA5HDAC2 | |
| SCHEMBL7583642 | 0.94 | MMP9 (0.70) | MMP9MMP2TACR1KCNA5HDAC2 | |
| SCHEMBL7665932 | 0.88 | MMP9 (1.00) | MMP9MMP2 | |
| SCHEMBL7669539 | 0.88 | MMP9 (1.00) | MMP9MMP2 | |
| SCHEMBL7878205 | 0.86 | MMP2 (0.69) | MMP9MMP2TACR1KCNA5 | |
| SCHEMBL29883928 | 0.86 | MMP2 (0.69) | MMP9MMP2TACR1KCNA5 | |
| SCHEMBL7894567 | 0.86 | MMP9 (0.66) | MMP9MMP2TACR1KCNA5 | |
| SCHEMBL7587014 | 0.82 | MMP9 (0.88) | MMP9MMP2 | |
| SCHEMBL9262155 | 0.82 | TACR1 (0.71) | MMP9MMP2TACR1KCNA5 | |
| SCHEMBL5099123 | 0.82 | MMP9 (0.68) | MMP9MMP2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |