Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673780 | 1.00 | MAPT (0.50) | MAPTALDH1A1PKMHTTCCKBR | |
| SCHEMBL4346709 | 0.85 | MAP3K7 (0.48) | MEN1RAB9AKMT2AHSD17B10HDAC1 | |
| SCHEMBL4346713 | 0.85 | MAP3K7 (0.48) | MEN1RAB9AKMT2AHSD17B10HDAC1 | |
| SCHEMBL5260195 | 0.84 | MAPT (0.47) | MAPTALDH1A1PKMHTTCCKBR | |
| SCHEMBL5260200 | 0.84 | MAPT (0.47) | MAPTALDH1A1PKMHTTCCKBR | |
| SCHEMBL5260132 | 0.81 | MAPT (0.48) | MAPTALDH1A1PKMHTTCCKBR | |
| SCHEMBL5260140 | 0.81 | MAPT (0.48) | MAPTALDH1A1PKMHTTCCKBR | |
| SCHEMBL4348573 | 0.78 | HDAC3 (0.49) | MEN1RAB9AKMT2AHSD17B10HDAC1 | |
| SCHEMBL4348583 | 0.78 | HDAC3 (0.49) | MEN1RAB9AKMT2AHSD17B10HDAC1 | |
| SCHEMBL4343457 | 0.78 | PRKD3 (0.53) | PKMMAPK8CDK2CDK5NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335342-B1 | 1H-PYRROLO(2,3-B)PYRIDINE DERIVATIVES; ANTICARCINOGENIC, ANTIMETASTASIS, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-01-01 | — | — | US | claimed |