Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231243 | 0.87 | TSHR (0.42) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7717027 | 0.82 | TSHR (0.38) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL7674087 | 0.82 | TSHR (0.41) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6736896 | 0.80 | POLB (0.47) | TSHRALDH1A1MAPTGAAPOLB | |
| SCHEMBL16599724 | 0.76 | MAPT (0.44) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL26513174 | 0.76 | DYRK1A (0.42) | TSHRALDH1A1MAPTGAAPOLB | |
| SCHEMBL483553 | 0.74 | CYP19A1 (0.46) | TSHRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL10070159 | 0.73 | TSHR (0.61) | TSHRALDH1A1MAPTGAAPOLB | |
| SCHEMBL338999 | 0.73 | POLB (0.50) | ALDH1A1NPC1RAB9AGAAPOLB | |
| SCHEMBL30934831 | 0.73 | POLB (0.50) | ALDH1A1NPC1RAB9AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |