Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674081 | 1.00 | KMT2A (0.55) | KMT2AKDM4EALDH1A1NPC1TGFBR1 | |
| SCHEMBL7003196 | 0.92 | LY96 (0.54) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL7676325 | 0.92 | LY96 (0.54) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL7676274 | 0.84 | FLT3 (0.64) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL7005500 | 0.84 | FLT3 (0.64) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL6997417 | 0.81 | MAPT (0.49) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL7676397 | 0.81 | MAPT (0.49) | KMT2AKDM4EALDH1A1NPC1MAPT | |
| SCHEMBL7002930 | 0.81 | RAB9A (0.53) | KMT2ANPC1MAPTMEN1NFKB1 | |
| SCHEMBL7674468 | 0.81 | RAB9A (0.53) | KMT2ANPC1MAPTMEN1NFKB1 | |
| SCHEMBL9366047 | 0.75 | KDM4E (0.65) | KMT2AKDM4EALDH1A1NPC1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |