Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5100736 | 0.93 | DPP4 (0.39) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5093331 | 0.91 | ALDH1A1 (0.44) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5093866 | 0.87 | DPP4 (0.45) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5091748 | 0.85 | MAPK8 (0.47) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5091685 | 0.85 | MAPK8 (0.43) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5092542 | 0.84 | MAPK8 (0.45) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5094058 | 0.83 | POLB (0.43) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5093426 | 0.83 | PKM (0.49) | DPP4DPP7ALDH1A1MAPK8GSK3B | |
| SCHEMBL5093437 | 0.82 | MAPK8 (0.41) | DPP4DPP7MAPK8GSK3BMKNK1 | |
| SCHEMBL6085442 | 0.82 | MAPT (0.43) | DPP4ALDH1A1GSK3BMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417185-B1 | HETEROCYCLIC ENZYME INHIBITORS | CHIRON CORPORATION | 2002-07-09 | — | — | US | disclosed |